I think it's usually a commitment to widen the slots to accommodate ta heavier gauge. And, of course, that is just one piece of the bigger set up picture. Truss rod tightening to correct relief and trem claw/spring tension adjustments for the additional string set tension would also need to be evaluated and addressed. All normal and basic set up stuff but that is a pretty large step up in gauge. And widening the slots, especially .010 on the lowest string, is more that what is the usual recommended latitude of .003-.004 where you can more easily get away with smaller changes in string set gauges, say in the .009 to .010 to .011 range for standard six string sets. So returning to the .054 sets might be a challenge if you alter the nut sluts that much. I do think that ultimately you should set up for what you prefer. Replacing the nut is not that big a deal and probably readily available from EBMM parts so don't let that dissuade you from making the guitar work for you.
I personally use the EB 2241 hybrid sets on everything and the .046 E string is slightly larger than the OEM .042 E string, so I tweak that a bit and all is well. And I would likely have no problem returning to a .042 if need be because it's not widened by all that much. But .010, or more if your going to a .070, is a commitment.
