The game changer is kind of like the Boogie Tri-axis of guitars. They can be really intimidating, but in the end it's more about being able to expand what the guitar is capable of, right on the guitar. I think you get 15 presets with just using the controls on the guitar? And if you've got the piezo that can be mixed in at will.
Compare that to a regular guitar, where you get 5 standard presets, or one like the Steve Morse, which has 11 pickup settings, but you've gotta work a two way toggle, a three way selector ,and a three way toggle to get those.
With the game changer, you've got them ready to go, just flip flip flip.
This also means that you can set up the guitar to have a non standard bunch of settings, kinda like how the St Vincent guitar has a 5 way switch with three pickups, but does not use the standard pickups you would usually select.
In other words, it give you unlimited choices, just like some of the high end modeling/profiling preamps. If you like that level of control, it may be worth looking at.