OK, LMII into MB 2x10 vs. EBS HD350 into EBS 4x10Neo:
I find the MB to be more of a closed, tight, articulate, natural sound. It is very versatile and clean. The VLE and VPF knobs give you fast access to dramatic tone change. It is very light weight and still sounds very big.
The EBS is a more open, colored sound. It's not as natural and tight as the MB. It is versatile, but takes more time to change the tone than the MB. It is also substantially heavier and bigger and sounds only minimally bigger than the MB. The EBS has a nice built in compressor and I like the "drive function". I also like that the EBS's Direct Out is pre/post EQ selectable.
I have not yet used the MB in a band setting, I will be doing that later on today. Will let you know how that goes.
Although the EBS and the MB are two quite different animals, I do prefer the MarkBass as it is lighter, easier to tweak the tone, and it's hard to get a bad tone out of it.