Mostly - if it works and you like the sound of it, buy it. That's the most important thing. Valves are consumable, i.e. they may eventually wear out and need replacement, just like guitar strings or sparks plugs in a car. But that's not really a problem and Mesa amps are designed to simplify that process (provided you buy their brand of valves, which you are not obliged to do). And there a bunch of mesa fans here (and Mesa have their own forum) so replacements need not be a scary ordeal.
Like buying a used car, when buying a used amp you can never be 100% sure that there wont be issues down the road but that's why you test drive and kick the tires and try to buy from somebody you trust. (And if the seller has original receipts and/or service info, even better).
Test the amp and see if you like it and how it sounds. If you really like the sound of the amp, if it's not too loud or too quite or too heavy and it's within your budget then buy it. And be honest with yourself too - if 60% of your playing is clean tones, probably not a good idea to settle for a clean tone that doesn't float your boat because the death metal sounds are sublime.