The Custom Dimarzios in my ASS are all I need, I would never swap them out for others. I have in the past on non EBMM guitars and I have had some great results.
I once bought a used ASS with the Dimarzios swapped over to Seymour Duncans. When I decided to pass the guitar on, it was worth significantly less (the previous owner had sold the Dimarzios). If you swap them out, hold on to the stock ones.
I swapped the stock pickups (custom neck, D-Sonic) in my JP6 with a set of Alnico Bareknucle Nailbombs and I'm pretty happy. A bit more responsive to volume and attack, and more of a vintage hot flavor, especially in the bridge.
That said, you can pry the stock custom neck from that JP6 out of my cold dead hands. I love that pickup, and even though I'm not using it, I'm happy to have it. I know it's essentially an Air Norton, but it's MINES.
Also, I don't know that I'd swap the pickups out of an Axis. Every time I've played one, I've been pretty happy with the stock dimarzios
I found the axis pickups really depend on which guitar they are in.
Love them in my Albert Lee HH due to the mahogany body; never liked them in my 25th.
I dropped in a set of David Allen Dirty Cats in the 25th and haven't looked back. Amazing tones.
I also, replaced the humbucker in my Sil Special with a JB, which works great for me; but I wouldn't replace the single coils as I think they sound amazing!